What Conditions Can Orthobiologics Treat?

The musculoskeletal system is the body’s interconnected network of bones, muscles, tendons, ligaments and connective tissues that helps you move and perform tasks of everyday living. But if injury or disease such as degenerative arthritis cause parts of the system to break down, the result can be pain, swelling, weakness and stiffness.

The good news however, is that the body has regenerative properties that we can harness to treat orthopedic injuries involving the joints and soft tissues in the back, neck, knees, hips, elbows, shoulders, wrists and ankles.

Orthobiologics are natural substances such as cells, cell molecules and tissues derived from the patient’s own body that are harnessed to stimulate healing of orthopedic injuries or conditions.

What are the different types of Orthobiologics used in clinical practice?

  • Platelet Rich Plasma (PRP): Concentrated solution of platelets derived from the patient’s own blood which contain a significant amount of growth factors and proteins that promote tissue regeneration, decrease inflammation and encourage blood vessel formation. 
  • Cell Based Therapies: Cells taken from the patient’s own fat tissue (Microfragmented Adipose Tissue) or bone marrow (Bone marrow Aspiration Concentrate) contain adult stem cells that have the unique ability to renew themselves and develop into other cell types. They promote tissue healing, control inflammation and fight  infection.

Do Orthobiologics Work?

A nationwide review of nearly 9,500 patient assessments submitted by 65 physicians practicing regenerative medicine in 43 clinics in 25 states revealed that:

  • 73 percent of the patients treated with platelet rich plasma reported a meaningful reduction in pain within 12 months following treatment, especially those with tennis elbow (lateral epicondylitis) and knee osteoarthritis.
  • 70 percent of the patients treated with adipose tissue therapy reported a meaningful reduction in pain within 12 months following treatment, with strong evidence shown by those treated for knee osteoarthritis.
  •  61 percent of the patients treated with bone marrow aspirate reported a meaningful reduction in pain within 12 months following treatment, particularly those with knee osteoarthritis and low back pain.

This first-of-its-kind comprehensive review of patient-centered data reveals that for many patients, the regenerative power of orthobiologics provides new hope in treating orthopedic conditions without surgery. These outcomes, along with hundreds of published research on these treatments, provide evidence that the body’s own natural healing properties is a significant tool that physicians can use to provide orthopedic pain relief and to help their patients live a healthy, active live.

Drs. Christopher J. Rogers and Mary A. Ambach of San Diego Orthobiologics Medical Group together have successfully treated thousands of patients with PRP and cell-based treatments for more than three decades. Dr. Rogers is a co-author of “An Overview of Regenerative Treatments for Orthopedic Conditions: 2021 Outcomes Report” which aims to encourage innovative and effective regenerative treatments for orthopedic conditions.


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