Dec 4, 2024
Join us for an insightful webinar with Personalized Stem Cells and San Diego Orthobiologics Medical Group, featuring industry experts Bob Harman and Dr. Chris Rogers. Learn about the science of stem cells, the importance of stem cell banking, and treatment pathways available in the U.S. for stem cell therapies. Don’t miss this opportunity to explore how stem cells can be a part of your future health.
When: December 10, 2024
Time: 12:00pm PDT
Register for this FREE Webinar HERE.
Apr 29, 2024
We are pleased to announce that San Diego Orthobiologics Medical Group physicians, Dr. Christopher Rogers and Dr. Mary Ambach were first in the US to publish on the safety and efficacy of a GMP-manufactured stem cell product for patients with osteoarthritis. 1 This FDA / IRB approved study was sponsored by Personalized Stem Cells (PSC), a leader in stem cell research for orthopedic conditions. 2
Patients with moderate to severe knee osteoarthritis who had not responded to standard medical care were treated with PSC-01, an autologous, adipose-derived cell product, also known as stromal vascular fraction.
Stromal vascular fraction (SVF) is obtained from a patient’s own adipose tissue (fat) using a simple in-office procedure. Prior clinical trials outside the United States have shown that SVF therapy is safe and effective for knee osteoarthritis. In several clinical trials, adipose-derived cells have demonstrated a superior ability to reduce pain, improve function and promote cartilage regeneration than bone-marrow derived cells. 3, 4, 5
In this clinical trial, the treatment was shown to be safe, well-tolerated and effective. Most of the subjects had been advised to consider joint replacement surgery, however at one year follow-up, 79% were satisfied and able to avoid surgery altogether. In addition, a single treatment was shown to decrease pain, increase function and improve quality of life for up to 2.5 years.
Treatments that use a patient’s own cells represent an exciting advancement in the field of orthopedic regenerative medicine. SDOMG and PSC are committed to the responsible development of medical products that use a patient’s own cells to safely decrease pain and improve function. While SVF products require FDA approval, this treatment offers real hope to all patients who suffer with joint pain.
To learn more about your current treatment options for orthopedic conditions, please schedule a consultation with one of our physicians today:
San Diego Orthobiologics Medical Group
6125 Pasel Del Norte, Suite 100
Carlsbad, CA 92011
(760) 909-2355
https://sdomg.com
[email protected]
REFERENCES
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11036882/pdf/scd.2024.0008.pdf
- https://personalizedstemcells.com
- https://www.thekneejournal.com/article/S0968-0160(21)00192-7/abstract
- https://journals.sagepub.com/doi/abs/10.1177/03635465211014500
- https://journals.sagepub.com/doi/abs/10.1177/03635465211053893
Oct 13, 2022
As one the largest joints in the body, the knees often suffer the most from the wear-and-tear that comes with a lifetime of use (or abuse). Whether damaged by an injury such as a ligament or tendon tear, or simply worn down by years of standing, running, jumping, lifting, etc., the result is often the same: chronic pain, inflammation, and reduced movement.
Depending on the extent of the injury or damage to the knee, patients can often gain some temporary relief from steroid injections that decrease swelling or from other interventional treatments such as hyaluronic acid injections that increase lubrication in the joint. But when these options have been expended, many look to surgery as their last, best hope to repair the damage and bring sought-after pain relief.
But now, non-surgical cellular treatments are providing long-term relief to patients with knee pain by putting the body’s own natural healing abilities to work to undo the damage brought on by injury or degeneration.
How Do Cellular Treatments Work?
Known as regenerative medicine, cellular treatments harness powerful healing properties within the body’s building blocks—its own cells—to help repair and, in some cases, replace injured tissues. These treatments promote healing of injuries to the cartilage in the knee joint, as well as soft tissues such as tendons and ligaments in the knee.
To adhere to Federal Food and Drug Administration (FDA) guidelines, only autologous (from the patient’s own body) cellular products can be used to treat orthopedic conditions. Donor products, including cord or amniotic cells, are not approved to treat knee osteoarthritis or soft tissue injuries in the knee.
Cellular products are taken from the patient’s own blood, bone marrow, or fat (adipose) tissues to maximize the benefits of their unique healing properties:
- Platelet Rich Plasma: Platelets in blood release growth factors and proteins that promote tissue repair, while the plasma carries the hormones, electrolytes and nutrients required to nourish cells during the healing process. Platelet rich plasma treatments can be customized to create specific formulations for each type of tissue being treated (muscle, tendon, ligament, cartilage).
- Cellular Therapy: Cells derived from the patient’s own bone marrow or adipose (fat) tissue called “pericytes” produce molecules that spur the production of new blood vessels, awaken other stem cells and encourage newly forming cells to produce collagen and other proteins essential for creating new healthy tissues. These specific cells can develop into the specific kind of cell needed, whether that be tendon, ligament, cartilage, or bone.
After these products are removed from the patient, they are concentrated and reinjected directly to the injured area to address the degeneration or injury.
Do Cellular Treatments for the Knees Work?
Regenerative medicine practitioners have scores of anecdotal evidence from satisfied patients that support the powerful pain-relieving and healing properties of cellular treatments for the knees.
But because the field of regenerative medicine is relatively new, until recently, there has been a limited amount of clinical data to bolster this anecdotal evidence. We believe the quantitative, controlled data that clinical trials will produce will not only further the use of cellular treatments for orthopedic conditions but will also confirm what hundreds of our satisfied patients have been telling us for years: cellular treatments have helped their bodies heal naturally while allowing them to resume the activities that help them regain their quality of life.
The experts at SDOMG help patients with knee injuries and knee osteoarthritis find the relief they need using expert technology and treatments. To learn more about cellular therapy for knee injuries, contact SDOMG using the form below.
Feb 6, 2022
Whether due to degenerative arthritis or injury, the Agency for Healthcare Research and Quality reports that more than 450,000 total hip replacements are performed in the United States every year.[i]
Even though this is major surgery and requires hospitalization and lengthy rehab, many patients who suffer from chronic hip pain believe they have no other options.
Thanks to the advances in the field of regenerative medicine, they do.
Why Do My Hips Hurt?
Hip degeneration or tissue damage can result in pain, tenderness, “clicking” and reduced range of motion. Pain can be localized in the front, side, or back of the hip.
Hip pain can have many causes, including:
- Degenerative osteoarthritis. Occurs when the cartilage between the bones of the hip joint begins to break down, usually with age.
- Tendon tears and tendinosis. Overuse may result in a tear or degeneration of the tendons, the thick bands of tissue that attach the hip bones to neighboring muscles.
- Muscle or tendon strains. Often the result of repetitive motions that stretch the muscles, tendons, and ligaments that support the hips.
- Hip labral tear. The labrum is a ring of cartilage that covers the outside rim of the hip socket. It cushions the joint and helps hold the femur (thighbone) ball within your hip socket. Anyone who makes repetitive twisting movements of the hip joint can develop labral tears.
- Obesity. Carrying extra weight puts tremendous pressure on the hips and can significantly hasten joint degeneration.
- In some cases, congenital abnormalities may also cause hip pain, as can previous surgery or trauma.
Using the Body’s Natural Healing Abilities to Treat Hip Pain
For those suffering from chronic hip pain, regenerative biologic therapies are providing new hope for pain relief without major surgery.
Regenerative medicine specialists use the natural healing properties in the patient’s own cells to stimulate healing of damaged tissues, reduce inflammation, and in some cases, promote the growth of new cells.
There are two types of regenerative biologic therapies used in clinical practice to treat orthopedic conditions, including hip pain.
- Platelet Rich Plasma (PRP): A concentrated solution of platelets derived from the patient’s own blood which contains a significant amount of growth factors and proteins that promote tissue regeneration, decrease inflammation, and encourage blood vessel formation.
- Cell-Based Therapies: Cells taken from the patient’s own fat tissue (Microfragmented Adipose Tissue) or bone marrow (Bone Marrow Aspiration Concentrate) which contain adult stem cells that have the unique ability to renew themselves and develop into other cell types which promote tissue healing. These cells control pain, decrease inflammation, and fight infection.
How are these Biologic Therapies Performed?
Biologic therapies are injection procedures. Blood, bone marrow, or fat tissue is collected and processed, and then injected into the injured tissue on the same day. These procedures are performed on an out-patient basis and recovery begins at home within hours of the treatment. There are no large incisions, no lengthy hospitalizations, or rehab stays involved.
Most hip tendon injuries and osteoarthritis respond well to these orthobiologic treatments. Factors such as the degree of injury or degeneration, as well as the patient’s overall health, can impact the final outcomes, but for patients weighing invasive surgery, orthobiologics can provide an option for pain relief and healing without surgery.
To learn more about healing hip pain with biologic therapies, fill out the form below to learn more:
[i] https://orthoinfo.aaos.org/en/treatment/total-hip-replacement/
Aug 2, 2021
Dr. Mary Ambach lectures to physicians, orthopedic surgeons and other orthopedic practitioners on the use of Platelet Rich Plasma and Stem Cell Therapies for the Spine.
Dr. Ambach is one of the esteemed instructors in this Orthobiologic seminar who taught physicians on how to perform regenerative injections and diagnostic musculoskeletal ultrasound scans.
Dr. Ambach has served as faculty and speaker at regenerative conferences in and outside of the country. She has mentored many doctors all over the world in innovative procedures using cell therapies from our own bodies to heal our own orthopedic injuries.
Jun 25, 2021
The bones of the spine called vertebrae are separated by shock-absorbing discs that act as a cushion. These discs have a strong cartilaginous outer portion and a gel-like inner core. When these discs begin to break down from either age or injury, they can result in disc bulging or what is also known as disc herniation. The discs can also tear, decrease in height or dry out. These changes in the discs can cause pain and pressure on nearby nerves ( radiculopathy). They can also cause degeneration of nearby facet joints and narrowing of the canal (spinal stenosis).
Degenerative disc disease often occurs as part of the aging process. By age 40, it is estimated that 40 percent of the population will have some degree of degenerative disc disease and by age 80, that percentage doubles.[1]
Symptoms from degenerative disc include neck pain, back pain, muscle spasms or radiating pain to the arms or legs. Pain is typically worse with bending forward or prolonged sitting.
The current standard treatment for degenerative or herniated discs includes physical therapy, medications, injection therapy, and surgery. These aim to provide symptomatic relief of the pain but most do not improve the pathology or reverse the degenerative process.
Treatment with Bone marrow-derived cells has introduced a unique approach to alleviate pain and improve function by restoring and repairing tissue injury.
What is Bone Marrow Aspirate Concentrate (BMAC)?
The body’s bone marrow possesses unique properties that help the body heal itself naturally. It contains important therapeutic cells, growth factors and proteins that stimulate the body’s natural ability to improve circulation, decrease inflammation and heal injured tissues.
It also contains adult stem cells called Mesenchymal stem cells. These stem cells have the special ability to renew themselves and differentiate into bone, tendon, cartilage and muscle cells. These make them an ideal therapy for treating orthopedic injuries such as tendon tears, worn cartilage, and degenerated disc disease.
Bone marrow-derived cells have been shown to stimulate disc cell proliferation, increase disc support tissue, increase disc hydration, decrease inflammation, and support tissue healing.
How Effective is BMAC?
A study published by International Orthopedics reported the results of 26 patients suffering from degenerative disc disease and were candidates for major surgery such as spinal fusion or total disc replacement who underwent BMAC therapy to their discs. Three years later, 73% of these patients showed improvement in pain, 70% showed improvement in function, and 75% avoided surgery.[2]
A systematic review of seven clinical trials with a total of 97 patients and up to 72 months follow-up concluded that treatment with Bone Marrow-derived cells intradiscally showed significant improvement in pain and function with low re-injection or complication rates.
BMAC therapy is a minimally invasive, non-surgical procedure that does not require hospitalization or lengthy rehabilitation. Patients are generally able to begin physical therapy and gradual resumption of their daily activities within a week.
For patients who suffer from chronic low back pain from degenerative disc disease and failed standard conservative therapy, BMAC therapy performed by an experienced regenerative medicine specialist can provide an innovative, non-surgical treatment solution. Schedule a consultation with our renowned regenerative medicine physicians to see if you are a candidate for these therapies before considering spinal surgery.
Drs. Christopher J. Rogers and Mary A. Ambach of San Diego Orthobiologics Medical Group together have successfully treated hundreds of patients with BMAC and other cell-based treatments for more than three decades. They have published authors and stem cell researchers. Their FDA-compliant facility in Carlsbad contains the most advanced Regenerative Medicine technology in San Diego and offers same-day treatments with the highest level of safety and efficacy.
[1] https://pubmed.ncbi.nlm.nih.gov/23074480/[1]
[2] https://pubmed.ncbi.nlm.nih.gov/28748380/
[3] https://www.cureus.com/articles/36347-systematic-review-is-intradiscal-injection-of-bone-marrow-concentrate-for-lumbar-disc-degeneration-effective
