SDOMG Webinar: Platelet Dose Matters
In this webinar, Dr. Evangelista and Dr. Rogers discuss the latest clinical research regarding dosing with Platelet-Rich Plasma treatments.
Non-Surgical Solutions: The Rise of Regenerative Medicine for Arthritis Treatment
Arthritis affects over 58 million adults in the United States alone, making it a leading cause of disability and pain. Traditionally, treatment options have focused on symptom management through medications, physical therapy, and, in severe cases, joint replacement surgery. However, recent advances in regenerative medicine are changing the landscape of arthritis care by offering promising, non-surgical alternatives that aim to repair and restore damaged tissues.
In this post, we’ll explore the latest regenerative medicine techniques used to treat arthritis, how they work, and why they’re generating excitement among physicians and patients alike.
Understanding Arthritis and Its Impact
Arthritis is not a single disease but a term that covers more than 100 different types of joint conditions. The most common forms are osteoarthritis (OA) and rheumatoid arthritis (RA):
- Osteoarthritis is a degenerative joint disease where the cartilage that cushions bones wears down over time.
- Rheumatoid arthritis is an autoimmune condition where the immune system attacks the synovial lining of the joints, causing inflammation and tissue damage.
Regardless of the type, arthritis often leads to joint pain, stiffness, decreased mobility, and a diminished quality of life.
Why Patients Seek Non-Surgical Options
Joint replacement surgery, while effective, comes with risks: infection, blood clots, lengthy recovery periods, and even the potential for implant failure over time. Many patients are not ready—or suitable candidates—for surgery and seek less invasive options to manage symptoms and improve joint function.
That’s where regenerative medicine steps in.
What Is Regenerative Medicine?
Regenerative medicine harnesses the body’s natural healing mechanisms to repair or replace damaged tissues, including cartilage, ligaments, tendons, and even bone. These treatments aim to not only reduce symptoms but also to slow or potentially reverse the progression of arthritis.
The most promising regenerative therapies for arthritis include:
- Platelet-Rich Plasma (PRP) Therapy
- Cell-Based Therapy
- Prolotherapy
Let’s break down each of these innovative techniques.
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Platelet-Rich Plasma (PRP) Therapy
PRP therapy involves drawing a small amount of the patient’s blood, processing it to concentrate the platelets, and then injecting this platelet-rich plasma into the affected joint.
How It Works:
Platelets contain growth factors that help stimulate tissue regeneration and reduce inflammation. When injected into an arthritic joint, PRP can:
- Promote cartilage healing
- Decrease pain and stiffness
- Improve joint function
Clinical Evidence:
Studies have shown PRP can be more effective than corticosteroids or hyaluronic acid injections in relieving knee osteoarthritis symptoms. Results are typically seen within weeks and can last for several months or even over a year.
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Cell-Based Therapy
Stem cells are undifferentiated cells capable of transforming into various tissue types, including cartilage. In arthritis treatment, mesenchymal stem cells (MSCs) are commonly harvested from a patient’s bone marrow or adipose (fat) tissue and injected into the joint.
How It Works:
Once inside the joint, stem cells can:
- Stimulate repair of damaged cartilage
- Modulate inflammation
- Recruit other cells to aid in tissue regeneration
Clinical Evidence:
Early studies have reported significant improvements in pain, mobility, and cartilage thickness following stem cell injections. While more research is needed to establish standardized protocols, the outlook is encouraging—especially for early to moderate osteoarthritis.
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Prolotherapy
Prolotherapy is a regenerative injection technique that involves injecting a natural irritant—often a dextrose (sugar) solution—into the joint or surrounding ligaments and tendons.
How It Works:
The solution triggers a localized inflammatory response, prompting the body to send healing cells to the area. Over time, this can strengthen connective tissues and stabilize the joint.
Who It’s For:
Prolotherapy is particularly effective for patients with joint instability, ligament laxity, or early-stage arthritis. It’s less commonly used for severe osteoarthritis but can still play a role as part of a broader regenerative plan.
Benefits of Regenerative Medicine for Arthritis
- Minimally Invasive: Most procedures are outpatient and involve little to no downtime.
- Reduced Dependence on Medications: Patients may rely less on NSAIDs, opioids, or corticosteroids.
- Slowed Disease Progression: Some therapies show the potential to halt or even reverse cartilage loss.
- Improved Quality of Life: Many patients report enhanced mobility, reduced pain, and greater participation in daily activities.
Important Considerations
Not a One-Size-Fits-All Solution
Regenerative therapies work best in the early to moderate stages of arthritis. They may not be as effective for patients with advanced joint deterioration.
Costs and Coverage
These treatments are often not covered by insurance and can range from a few hundred to several thousand dollars per session. However, many patients find the cost worthwhile for the benefits they experience.
Choose a Qualified Provider
It’s essential to seek care from physicians who specialize in regenerative medicine and follow best practices for safety, preparation, and delivery. Improper technique or unregulated products can result in complications.
The Future of Arthritis Treatment
Regenerative medicine is rapidly evolving. As research deepens and technology advances, these therapies may soon become mainstream components of arthritis care. Clinical trials are underway to determine long-term outcomes, best candidates, and optimal treatment protocols.
What’s exciting is that these approaches shift the paradigm from merely managing symptoms to actively promoting healing—a revolutionary step for the millions living with arthritis.
Final Thoughts
If you’re struggling with arthritis pain and looking for alternatives to surgery, regenerative medicine offers a promising path forward. From PRP to stem cells and beyond, these innovative techniques can help restore joint health, improve function, and reduce your reliance on medications.
Always consult a qualified healthcare professional to determine which therapy, if any, is right for you. With the right approach, living well with arthritis is not only possible—it’s becoming increasingly probable.
Interested in learning more about regenerative treatments? Talk to a regenerative medicine specialist or rheumatologist to explore your options based on your specific type of arthritis and stage of progression.
What is Lipogems and How Does it Work for Healing?
In recent years, medical science has made significant advancements in regenerative medicine, one of which is Lipogems. This innovative technique utilizes adipose (fat) tissue to harness the body’s natural healing properties. Lipogems stands out as a minimally invasive procedure that offers promising results for patients suffering from various musculoskeletal conditions. By employing the unique characteristics of adipose-derived stem cells, it aims to reduce inflammation and promote tissue repair.
The essence of Lipogems lies in its ability to extract and process adipose tissue, which is abundant in stem cells and growth factors. This procedure not only provides a source of regenerative cells but also offers a scaffold for tissue healing. As a result, it has garnered attention in the fields of orthopedics, sports medicine, and aesthetic treatments, making it a versatile option for many patients.
As more individuals seek alternatives to traditional surgical methods, the demand for therapies like Lipogems continues to rise. This article aims to delve into the science behind Lipogems, its procedural aspects, and the conditions it effectively treats, providing a comprehensive understanding of this revolutionary healing technique.
The Science Behind Lipogems: Understanding Adipose-Derived Stem Cells
At the core of Lipogems therapy are adipose-derived stem cells (ADSCs). These cells are unique due to their ability to differentiate into various cell types, including bone, cartilage, and fat cells. This versatility makes them invaluable in regenerative medicine. Research has shown that ADSCs possess anti-inflammatory properties, which can significantly aid in the healing process.
Adipose tissue is rich in these stem cells, making it an excellent source for regenerative therapies. Unlike other sources, such as bone marrow, adipose tissue can be harvested easily and in larger quantities, providing a substantial number of stem cells for therapeutic use. Additionally, the processing of adipose tissue in Lipogems preserves the architecture and microenvironment necessary for stem cell function, enhancing their effectiveness.
Understanding the role of these stem cells is crucial for appreciating how Lipogems works. When injected into damaged tissues, ADSCs promote healing by stimulating the regeneration of damaged cells and reducing inflammation. This natural approach aligns with the body’s intrinsic healing mechanisms, offering a safer and often more effective alternative to conventional treatments.
How Lipogems Works: Step-by-Step Process
The Lipogems procedure is designed to be efficient and minimally invasive. Here’s a step-by-step overview of how it works:
- Consultation and Assessment: The process begins with a thorough consultation where the physician evaluates the patient’s medical history and current condition. This assessment helps determine if Lipogems is a suitable option for the individual.
- Harvesting Adipose Tissue: Once deemed appropriate, a small amount of adipose tissue is harvested, typically from the abdomen or thighs. This is done using liposuction, a minimally invasive technique that involves making small incisions to extract the fat.
- Processing the Tissue: The harvested adipose tissue is then processed using the Lipogems technology, which involves washing and breaking down the fat. This process isolates the stem cells and growth factors while preserving the natural extracellular matrix, which is vital for healing.
- Injection into the Target Area: After processing, the resulting solution containing stem cells and growth factors is injected into the area requiring treatment. This could be a joint, tendon, or other damaged tissue, depending on the patient’s condition.
- Post-Procedure Care: Following the injection, patients are provided with care instructions to facilitate healing. This may include rest, physical therapy, or follow-up appointments to monitor progress.
By understanding this step-by-step process, patients can appreciate the meticulous care involved in Lipogems, ensuring that they receive the best possible treatment tailored to their needs.
Conditions Treated with Lipogems Technology
Lipogems technology has shown efficacy in treating a variety of conditions. Here are some of the most common applications:
- Osteoarthritis: This degenerative joint disease often results in significant pain and reduced mobility. Lipogems can help by restoring joint function and alleviating discomfort through its regenerative effects.
- Tendinopathies: Conditions such as tennis elbow and Achilles tendonitis can benefit from Lipogems injections. The stem cells work to repair damaged tissues, promoting healing and reducing pain.
- Cartilage Damage: Injuries to cartilage can lead to long-term complications. Lipogems provides a source of cells that can regenerate cartilage, potentially delaying or avoiding joint replacement surgery.
- Sports Injuries: Athletes frequently face injuries that require quick and effective treatment. Lipogems has emerged as a promising option for treating soft tissue injuries, allowing athletes to return to their sport sooner.
- Aesthetic Applications: Beyond orthopedic uses, Lipogems can also be utilized in cosmetic procedures, such as facial rejuvenation, where regenerative properties can improve skin texture and volume.
The versatility of Lipogems makes it an attractive option for a range of conditions, allowing patients to explore alternatives to traditional treatment methodologies.
The Lipogems Procedure: What to Expect
Patients considering Lipogems can expect a well-structured procedure that prioritizes comfort and safety. Here’s what to anticipate during the entire process:
- Preparation: Before the procedure, patients are advised to follow specific guidelines, such as avoiding blood thinners and alcohol. This preparation helps minimize complications and ensures a smoother experience.
- Local Anesthesia: To enhance comfort during the fat harvesting process, local anesthesia is administered. This allows the procedure to be performed with minimal discomfort, ensuring that patients remain relaxed throughout.
- Fat Harvesting and Processing: The liposuction process typically takes around 30 minutes, followed by the processing of the adipose tissue. The entire procedure, from harvesting to injection, can be completed in about one to two hours.
- Injection and Follow-Up: After processing, the injection is performed using ultrasound guidance for precision. Patients usually experience minimal downtime, with many resuming normal activities within a few days. Follow-up appointments are scheduled to monitor progress and assess the effectiveness of the treatment.
Patients can feel reassured knowing that the Lipogems procedure is designed to be efficient, with a focus on achieving optimal results while ensuring their comfort throughout the process.
Recovery and Results: Healing with Lipogems
Understanding the recovery process is vital for patients undergoing Lipogems treatment. The timeline for recovery can vary based on the individual and the condition being treated. However, most patients can expect the following:
- Initial Recovery: After the procedure, patients may experience mild swelling or discomfort in the treated area. This is typically manageable with over-the-counter pain relievers and should subside within a few days.
- Physical Activity: Patients are generally encouraged to resume light activities shortly after the procedure, while more strenuous activities may be restricted for a few weeks. Adhering to the physician’s recommendations regarding physical activity ensures optimal healing.
- Long-Term Results: Many patients begin to notice improvements in their symptoms within several weeks. However, the full benefits of Lipogems may take several months to manifest as the body continues to heal and regenerate damaged tissues.
The regenerative capabilities of Lipogems can lead to significant improvements in pain relief and mobility, with many patients reporting enhanced quality of life post-treatment.
Who is a Good Candidate for Lipogems Treatment?
Determining eligibility for Lipogems treatment involves a careful evaluation by a qualified healthcare professional. Generally, good candidates include:
- Individuals with Chronic Pain: Patients suffering from chronic joint pain, tendonitis, or injuries that have not responded to conventional treatments may benefit from Lipogems.
- Active Individuals: Those who lead an active lifestyle, including athletes, who seek quick recovery from injuries often find Lipogems to be an appealing option.
- Patients with Degenerative Conditions: Individuals with conditions like osteoarthritis or cartilage damage may find relief through Lipogems, especially if they wish to avoid surgical interventions.
However, not everyone may be suitable for this treatment. Factors such as underlying health conditions, obesity, or the presence of infections may disqualify some individuals. A thorough consultation with a healthcare provider is essential to assess suitability and discuss potential risks and benefits.
Is Lipogems Right for You?
As regenerative medicine continues to evolve, Lipogems emerges as a promising option for those seeking alternatives to traditional treatments. Its minimally invasive nature, coupled with the use of the body’s own healing mechanisms, presents patients with an opportunity for recovery without the risks associated with more invasive surgeries.
Considering the various conditions treated by Lipogems and the positive outcomes reported by many patients, it is worth exploring whether this innovative therapy aligns with their health needs. Consulting a knowledgeable healthcare provider can help individuals determine if Lipogems is the right choice for them and provide personalized insights into the potential benefits and expected results.
If you’re interested in learning more about Lipogems and how it can help you on your healing journey, reach out to a qualified physician today to explore your options.
FREE Webinar: Discover the Future of Stem Cell Therapy with PSC & SDOMG
Join us for an insightful webinar with Personalized Stem Cells and San Diego Orthobiologics Medical Group, featuring industry experts Bob Harman and Dr. Chris Rogers. Learn about the science of stem cells, the importance of stem cell banking, and treatment pathways available in the U.S. for stem cell therapies. Don’t miss this opportunity to explore how stem cells can be a part of your future health.
When: December 10, 2024
Time: 12:00pm PDT
Dr. Christopher Rogers and Dr. Mary Ambach Publish the First US FDA-Approved Human Clinical Trial on GMP-Manufactured Stem Cell Therapy
We are pleased to announce that San Diego Orthobiologics Medical Group physicians, Dr. Christopher Rogers and Dr. Mary Ambach were first in the US to publish on the safety and efficacy of a GMP-manufactured stem cell product for patients with osteoarthritis. 1 This FDA / IRB approved study was sponsored by Personalized Stem Cells (PSC), a leader in stem cell research for orthopedic conditions. 2
Patients with moderate to severe knee osteoarthritis who had not responded to standard medical care were treated with PSC-01, an autologous, adipose-derived cell product, also known as stromal vascular fraction.
Stromal vascular fraction (SVF) is obtained from a patient’s own adipose tissue (fat) using a simple in-office procedure. Prior clinical trials outside the United States have shown that SVF therapy is safe and effective for knee osteoarthritis. In several clinical trials, adipose-derived cells have demonstrated a superior ability to reduce pain, improve function and promote cartilage regeneration than bone-marrow derived cells. 3, 4, 5
In this clinical trial, the treatment was shown to be safe, well-tolerated and effective. Most of the subjects had been advised to consider joint replacement surgery, however at one year follow-up, 79% were satisfied and able to avoid surgery altogether. In addition, a single treatment was shown to decrease pain, increase function and improve quality of life for up to 2.5 years.
Treatments that use a patient’s own cells represent an exciting advancement in the field of orthopedic regenerative medicine. SDOMG and PSC are committed to the responsible development of medical products that use a patient’s own cells to safely decrease pain and improve function. While SVF products require FDA approval, this treatment offers real hope to all patients who suffer with joint pain.
To learn more about your current treatment options for orthopedic conditions, please schedule a consultation with one of our physicians today:
San Diego Orthobiologics Medical Group
6125 Pasel Del Norte, Suite 100
Carlsbad, CA 92011
(760) 909-2355
REFERENCES
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11036882/pdf/scd.2024.0008.pdf
- https://personalizedstemcells.com
- https://www.thekneejournal.com/article/S0968-0160(21)00192-7/abstract
- https://journals.sagepub.com/doi/abs/10.1177/03635465211014500
- https://journals.sagepub.com/doi/abs/10.1177/03635465211053893
How Can Cellular Therapy Heal Injured Knees?
As one the largest joints in the body, the knees often suffer the most from the wear-and-tear that comes with a lifetime of use (or abuse). Whether damaged by an injury such as a ligament or tendon tear, or simply worn down by years of standing, running, jumping, lifting, etc., the result is often the same: chronic pain, inflammation, and reduced movement.
Depending on the extent of the injury or damage to the knee, patients can often gain some temporary relief from steroid injections that decrease swelling or from other interventional treatments such as hyaluronic acid injections that increase lubrication in the joint. But when these options have been expended, many look to surgery as their last, best hope to repair the damage and bring sought-after pain relief.
But now, non-surgical cellular treatments are providing long-term relief to patients with knee pain by putting the body’s own natural healing abilities to work to undo the damage brought on by injury or degeneration.
How Do Cellular Treatments Work?
Known as regenerative medicine, cellular treatments harness powerful healing properties within the body’s building blocks—its own cells—to help repair and, in some cases, replace injured tissues. These treatments promote healing of injuries to the cartilage in the knee joint, as well as soft tissues such as tendons and ligaments in the knee.
To adhere to Federal Food and Drug Administration (FDA) guidelines, only autologous (from the patient’s own body) cellular products can be used to treat orthopedic conditions. Donor products, including cord or amniotic cells, are not approved to treat knee osteoarthritis or soft tissue injuries in the knee.
Cellular products are taken from the patient’s own blood, bone marrow, or fat (adipose) tissues to maximize the benefits of their unique healing properties:
- Platelet Rich Plasma: Platelets in blood release growth factors and proteins that promote tissue repair, while the plasma carries the hormones, electrolytes and nutrients required to nourish cells during the healing process. Platelet rich plasma treatments can be customized to create specific formulations for each type of tissue being treated (muscle, tendon, ligament, cartilage).
- Cellular Therapy: Cells derived from the patient’s own bone marrow or adipose (fat) tissue called “pericytes” produce molecules that spur the production of new blood vessels, awaken other stem cells and encourage newly forming cells to produce collagen and other proteins essential for creating new healthy tissues. These specific cells can develop into the specific kind of cell needed, whether that be tendon, ligament, cartilage, or bone.
After these products are removed from the patient, they are concentrated and reinjected directly to the injured area to address the degeneration or injury.
Do Cellular Treatments for the Knees Work?
Regenerative medicine practitioners have scores of anecdotal evidence from satisfied patients that support the powerful pain-relieving and healing properties of cellular treatments for the knees.
But because the field of regenerative medicine is relatively new, until recently, there has been a limited amount of clinical data to bolster this anecdotal evidence. We believe the quantitative, controlled data that clinical trials will produce will not only further the use of cellular treatments for orthopedic conditions but will also confirm what hundreds of our satisfied patients have been telling us for years: cellular treatments have helped their bodies heal naturally while allowing them to resume the activities that help them regain their quality of life.
The experts at SDOMG help patients with knee injuries and knee osteoarthritis find the relief they need using expert technology and treatments. To learn more about cellular therapy for knee injuries, contact SDOMG using the form below.