Prolotherapy, also known as proliferative therapy, is a treatment used to boost the body’s own natural healing capabilities to reduce inflammation, stimulate proliferation of injured tissue and relieve pain.
This is a minimally invasive therapy that involves injection of natural solutions to the injured tissue to stimulate healing. The main ingredient in the injection is dextrose, a sugar solution, which acts as an irritant to the body.The body reacts to the dextrose by stimulating repair and activating its natural healing abilities. The patient experiences relief as the injured tissue strengthens and heals.
What Conditions Can Prolotherapy Treat?
Prolotherapy can be used to treat any number of orthopedic conditions including:
Sacroiliac joint ( SI joint) dysfunction
What Does Prolotherapy Entail?
Your physician will first complete an appropriate clinical evaluation and diagnostic testing to determine if you are a good candidate for prolotherapy. The procedure is a minimally invasive procedure performed in a medical clinic using local anesthesia. You may be asked to discontinue anti-inflammatory medications 3-5 days prior to the procedure.The procedure is performed using ultrasound or fluoroscopic guidance for precise localization of target and delivery of the solution. A small needle is used to inject the prolotherapy solution to the injured area using imaging guidance. Depending on the extent of the injury, a series of injections performed a few weeks apart may be needed for a successful treatment. You will be asked to take it easy for a few days and return to normal activity and exercises after 3-5 days. The procedure is very well tolerated with no downtime.
How Effective is This Type of Therapy?
Prolotherapy is a proven treatment that has been in use for more than 80 years and is practiced by physicians around the world. A review in the US National Library of Medicine of the National Institutes of Health evaluated 32 studies on dextrose prolotherapy for chronic musculoskeletal pain. It concluded that “dextrose prolotherapy has been demonstrated to be efficacious and should be considered as a treatment for pain and dysfunction associated with chronic musculoskeletal conditions, particularly tendinopathies and osteoarthritis.”[i]
A good review of prolotherapy treatments can be found here and here.
To learn more about SDOMG and how they have successfully utilized prolotherapy for more than three decades, fill out the form below:
Drs. Mary A. Ambach and Chris Rogers of San Diego Orthobiologics Medical Group have successfully treated hundreds of patients with prolotherapy and other cell-based treatments for more than three decades. Their state -of- the- art facility in Carlsbad offers the most advanced Regenerative Medicine treatments in San Diego with the highest level of safety and efficacy.
Like many things in life, when it comes to body fat moderation is key. Your body needs fat tissue to help its vital systems including the cardiovascular, endocrine, reproductive and central nervous systems, function properly. But too much body fat is harmful and can lead to increased risk for chronic conditions such as heart disease, diabetes and arthritis.
Now, regenerative medicine specialists are putting fat’s natural healing abilities to work to address common orthopedic conditions such as joint and tendon injuries.
What is Micro-fragmented Adipose Tissue?
Fat or adipose tissue is rich in healing cells like mesenchymal stem cells or MSCs, growth factors and other proteins that can assist in healing tissues. Innovative procedures, like Lipogems® uses the body’s own fat with a patented system that processes and resizes the adipose tissue. A small amount of fat is collected from the buttocks, abdomen or “love handles.” There is minimal manipulation of the tissue with no enzymatic digestion or addition of other biological or pharmacological agents.
The processed tissue is called Micro-fragmented Adipose Tissue (MFAT) and it is injected into injured areas using imaging guidance to help provide cushion and support the healing of damaged tissues. The entire procedure is performed in a doctor’s clinic without the need for sedation.
What Are the Outcomes for Lipogems®?
There are more than 70 research studies published in the peer-reviewed medical literature using this treatment with up to 3 years of follow-up. More than 90 percent of San Diego Orthobiologics Medical Group patients who underwent Lipogems® experienced significant relief with the treatment and were able to resume normal, pain-free physical activity. More than 35,000 procedures are performed worldwide with a low rate of minor complications and no major complications reported. There is no risk of rejection and low risk of infection since you are using your own tissue. Individual outcomes vary based on the extent of the injury or damage as well as the patient’s overall health and fitness levels.
Fat-derived cell based therapies is a great non-surgical treatment option for patients with orthopedic injuries or conditions who failed standard therapies. Learn more about these therapies here and here. Schedule a consultation with our innovative Regenerative Medicine doctors to determine if you are a good candidate for these treatments.
Drs. Christopher J. Rogers and Mary A. Ambach of San Diego Orthobiologics Medical Group together have successfully treated thousands of patients with Lipogems® and other cell-based treatments for more than three decades. They are published authors and stem cell researchers. Their facility in Carlsbad contains the most advanced Regenerative Medicine technology in San Diego and offers same-day treatments with the highest level of safety and efficacy.
Dr. Christopher Rogers was honored to speak at the April 2021 La Jolla Golden Triangle Rotary Club meeting. Topics of the lecture included a history of stem cell therapy in San Diego and an update on FDA-approved clinical trials for knee osteoarthritis. To see a copy of the lecture, visit the San Diego Orthobiologics Medical Group YouTube channel or view the video linked below!
Regenerative medicine is a field in medicine that develops methods to regrow, repair, or replace damaged diseased cells, tissues or organs. Itutilizes the body’s natural healing processes to rebuild damaged tissues and heal injuries.In the field of orthopedics, regenerative medicine holds great promise for helping patients with injuries or degeneration involving the musculoskeletal system.
Damage to the joints, ligaments, tendons, or discs can lead to chronic pain in various parts of the body including:
Feet and ankles
Hands and wrists
Elbows and Shoulders
Regenerative medicine addresses the reason for the pain by helping to heal and create new healthy tissues.
How Does it Work?
Regenerative treatments for orthopedic conditions use the patient’s own blood and tissues from bone marrow or fat to kick-start the body’s own healing processes. These cells are removed from the patient and concentrated to isolate the healing proteins, molecules, and nutrients they contain. These super-healers are then re-injected into the site of damaged tissue to encourage new cell growth and healing.
The U.S. Food & Drug Administration (FDA) does not allow the use of embryonic cells or birth tissue products for treating orthopedic conditions. However regenerative medicine physicians can use FDA-compliant autologous cellular products to treat musculoskeletal problems.
These autologous cell therapies include:
Platelet Rich Plasma: Platelets in the patient’s own blood release growth factors and proteins that promote tissue repair, while the plasma carries the hormones, electrolytes and nutrients required to nourish cells during the healing process.
Cell Based Therapies: Adult Stem Cells taken from the patient’s own fat tissue (adipose) or bone marrow have the unique ability to develop into the specific kind of cell needed and possess molecules that direct other cells in the injured area to form new blood vessels, awaken other stem cells and encourage newly forming cells to produce collagen and other proteins essential for creating new healthy tissues.
Prolotherapy (Proliferative Therapy) is a Regenerative injection using natural medications, specifically dextrose, that help the body jump-start its own natural healing response when injected into the injured area.
Is Regenerative Medicine Painful?
For many years, patients with unresolved chronic orthopedic pain were left to consider surgery as their last option and best hope for long-term pain relief.But with advancements in regenerative medicine, these patients can avoid major surgery and lengthy rehabilitation.
Regenerative treatments are injection procedures and unlike surgery, they do not involve the pain or risk of large surgical incisions.Blood, bone marrow, or fat tissue is collected, processed, and injected into injured tissue on the same day. These procedures are typically performed on an out-patient basis and recovery begins at home within hours of the treatment.
Ask the Right Questions, Get the Best Results
When considering regenerative medicine treatments, it is important that you do your research in selecting a physician that is highly skilled and experienced in regenerative medicine. The following are questions that you need to ask before making your decision. Patients get the best outcomes when the answer is “yes” to all these questions.
Is the physician board-certified and specializes in diagnosing and treating orthopedic conditions?Examples include Physical Medicine and Rehabilitation, Sports Medicine, Orthopedics, Pain Management physicians.
Do you use appropriate, advanced, FDA-compliant devices in the preparation of the cellular products that can deliver the best results?
Are the treatments performed using imaging guidance to ensure precise delivery of the regenerative products to the site of the injury?
Is the practice compliant with FDA regulations?
Do you track your outcomes and present them at medical conferences or publish them in medical journals?
Drs. Christopher J. Rogers and Mary A. Ambach of San Diego Orthobiologics Medical Group together have successfully treated thousands of patients with PRP and cell-based treatments for more than three decades. They are published authors and stem cell researchers.Their facility in Carlsbad contains the most advanced Regenerative Medicine technology in San Diego and offers same-day treatments with the highest level of safety and efficacy
The physicians at San Diego Medical Group helped to create one of the largest Regenerative Medicine registries in the world. We would like to thank those patients who helped us to achieve this milestone. Our mission is to help patients make informed medical decisions about their healthcare.
By tracking the outcomes from Regenerative Medicine treatments, such as Platelet Rich Plasma (PRP) and other cell based therapies, DataBiologics intends to change the face of healthcare.
Regenerative medicine uses the natural healing capabilities of stem cells to help repair injured tissues. One of the biggest challenges facing practitioners of this exciting new medical subspecialty is helping patients understand that not all stem cells are the same.
The ABC’s of Stem Cells
Stem cells are unique because they have the ability to renew themselves and become different kinds of cells that are needed by the body. In fact, they are the only cells in the body that are capable of generating new cell types.[i]To better understand what kind of stem cells are used for orthopedic conditions, it is helpful to know that there are several different types.
Embryonic stem cells are derived from an embryo that develops from fertilized human eggs in the laboratory. They are used for research purposes only.There are no FDA approved treatments that use embryonic stem cells.
Stem cells derived from birth tissue products such as umbilical cord blood are approved for use in blood cancers and other blood disorders like sickle cell disease.However, the stem cells from umbilical cord blood and amniotic fluid are not approved by the US Food and Drug Administration (FDA) for any orthopedic indication. The safety and efficacy of these products have not been tested in orthopedic conditions and the FDA does not permit their use.
Mesenchymal stem cells (MSCs) are a specific type of adult stem cell that have the ability to differentiate into bone, cartilage and muscle cells.[ii] These stem cells are found in all tissues of our body in limited quantities, but they tend to exist in higher amounts in the bone marrow and adipose tissue (fat).For orthopedic applications, your physician may obtain these cells from your own (autologous) bone marrow or adipose tissue (fat).These tissues not only contain mesenchymal stem cells, they also contain other cells that are anti-inflammatory and regenerative. Once these cells are injected, they release hundreds of molecules that decrease inflammation, fight infection and repair injured tissues.
The Body: A Constant Work in Progress
There are more than 37 trillion cells in our body which are constantly dying and being replaced. There are more than 200 types of cells in our body and they each have different lifespans. Platelets live for a week, red blood cells live for about four months, bone and muscle cells live about 25 years, while brain cells can live a lifetime.
An injury or disease can hasten the death of cells. But often, the wear-and-tear of the natural aging process cause tissues to become damaged.Stem cell treatments enable regenerative medicine specialists to boost the body’s own natural healing abilities by bringing concentrated doses of these powerful building blocks directly to the site of injured or degenerated joint, cartilage or tissue.
Although regenerative medicine is a relatively new specialty within the field of orthopedics, cell-based treatments have been shown to be an effective non-surgical option for patients who have failed standard treatments or want to avoid surgery.
By combining the body’s own powerful healing capabilities with the latest in scientific and medical technology, orthopedic stem cell therapies provide lasting pain relief and help patients live their life fully.
Drs. Christopher Rogers and Mary A. Ambach have been providing cellular treatments for orthopedic conditions for more than three decades. Their clinical outcome data reveals that the majority of their patients are satisfied and successfully respond to these orthobiologic therapies which also demonstrate excellent safety.