Jan 15, 2025
As researchers and medical professionals delve deeper into the world of cellular therapy, understanding its efficacy has become a crucial area of focus. Efficacy, in this context, refers to the ability of a particular treatment or intervention to produce the desired therapeutic effect under controlled conditions. By examining the efficacy of cellular therapy, healthcare providers can make informed decisions about the most appropriate and effective treatment options for their patients, ultimately leading to better overall patient care and outcomes.
Understanding the Efficacy of Cellular Therapy
The efficacy of cellular therapy is a multifaceted concept, influenced by a variety of factors. To fully comprehend the effectiveness of this approach, it is essential to explore the various aspects that contribute to its success.
One of the key factors in determining the efficacy of cellular therapy is the specific type of cells being used. Different cell types, such as stem cells, immune cells, or tissue-specific progenitor cells, have unique properties and capabilities that can impact their therapeutic potential. The source of these cells, whether they are derived from the patient’s own body (autologous) or from a donor (allogeneic), can also play a significant role in the therapy’s efficacy.
Another crucial aspect is the method of cell delivery. Cellular therapies can be administered through various routes, such as intravenous infusion, direct injection into the target tissue, or even implantation of engineered tissue constructs. The choice of delivery method can significantly influence the cells’ ability to reach and integrate with the damaged or diseased area, ultimately affecting the overall efficacy of the treatment.
Furthermore, the specific medical condition being treated is a key determinant of cellular therapy’s efficacy. Different diseases and injuries may respond differently to the same cellular therapy, as the underlying pathophysiology and the cellular and molecular mechanisms involved can vary greatly. Consequently, the efficacy of cellular therapy may be more pronounced in certain disease states compared to others.
Factors Affecting the Efficacy of Cellular Therapy
The efficacy of cellular therapy is influenced by a complex interplay of various factors, both intrinsic and extrinsic to the therapy itself. Understanding these factors is crucial in optimizing the effectiveness of this innovative approach to healthcare.
Intrinsic Factors
- Cell Type and Source: As mentioned earlier, the specific type of cells used in the therapy, as well as their source (autologous or allogeneic), can significantly impact the efficacy of the treatment.
- Cell Potency and Function: The inherent potency and functional capabilities of the cells used in the therapy are critical determinants of their ability to effectively repair, regenerate, or modulate the target tissue or disease.
- Cell Viability and Purity: Maintaining the viability and purity of the cells throughout the manufacturing and delivery process is essential to ensure their optimal therapeutic potential.
- Cell Expansion and Manipulation: The methods used to expand and manipulate the cells, such as in vitro culture conditions and genetic engineering, can influence their therapeutic properties and efficacy.
Extrinsic Factors
- Delivery Route and Timing: The method and timing of cell delivery can greatly impact the cells’ ability to reach and engraft within the target tissue, thereby affecting the overall efficacy of the therapy.
- Microenvironmental Factors: The specific characteristics of the target tissue or disease environment, such as inflammation, hypoxia, or the presence of inhibitory factors, can influence the cells’ ability to survive, proliferate, and exert their intended therapeutic effects.
- Patient-Specific Factors: Individual patient characteristics, such as age, underlying health conditions, and immune status, can play a significant role in the efficacy of cellular therapy.
- Regulatory and Manufacturing Considerations: The regulatory framework and manufacturing processes involved in the development and production of cellular therapies can impact their quality, consistency, and ultimately, their efficacy.
Future Advancements and Potential of Cellular Therapy
As the field of cellular therapy continues to evolve, researchers and healthcare professionals are actively exploring new frontiers to further enhance the efficacy and potential of this innovative approach. Several exciting advancements and areas of exploration are shaping the future of cellular therapy:
- Stem Cell Technology: Ongoing research into the use of different types of stem cells, such as embryonic, induced pluripotent, and adult stem cells, is aimed at unlocking their full therapeutic potential and improving their efficacy in a wide range of medical applications.
- Genetic Engineering and Cell Modification: Advances in genetic engineering and cell manipulation techniques are enabling the development of genetically modified or engineered cells with enhanced therapeutic properties, potentially leading to improved efficacy and targeted treatments.
- Combination Therapies: The integration of cellular therapy with other treatment modalities, such as biomaterials, drugs, or even other cell-based approaches, is being explored to create synergistic effects and improve overall efficacy.
- Personalized Medicine: The growing emphasis on personalized and precision medicine is driving the development of tailored cellular therapies that are optimized for individual patient needs, taking into account their unique genetic, molecular, and clinical profiles.
- Improved Delivery and Targeting: Researchers are investigating innovative methods of cell delivery and targeting, such as the use of biomimetic materials, nanoparticles, or tissue-specific homing strategies, to enhance the cells’ ability to reach and integrate with the target tissue.
- Real-World Evidence and Data Analytics: The collection and analysis of real-world data on the use and outcomes of cellular therapies will provide valuable insights into their efficacy, safety, and long-term effects, ultimately informing clinical decision-making and driving further advancements.
The Promising Future of Cellular Therapy and Its Efficacy in Improving Patient Outcomes
As the field of cellular therapy continues to evolve, the promise of this innovative approach to healthcare becomes increasingly evident. By harnessing the inherent regenerative and therapeutic capabilities of living cells, cellular therapies hold the potential to revolutionize the way we treat a wide range of medical conditions, from chronic diseases to acute injuries.
The ongoing research and development in this field are steadily uncovering new ways to enhance the efficacy of cellular therapies. From advancements in stem cell technology and genetic engineering to the integration of personalized medicine and improved delivery methods, the future of cellular therapy looks increasingly bright.
As healthcare providers and researchers work together to better understand the factors that influence the efficacy of cellular therapies, they can make more informed decisions about the most appropriate and effective treatment options for their patients. This, in turn, can lead to improved patient outcomes, reduced reliance on traditional, more invasive treatments, and a greater overall quality of life for those who benefit from these innovative therapies.
To learn more about the latest advancements in cellular therapy and how it can benefit your healthcare needs, schedule a consultation with one of the experts at San Diego Orthobiologics Medical Group today. Our team is dedicated to providing personalized, evidence-based solutions to help you achieve your optimal health and wellness.
Jul 12, 2024
PRP (Platelet-Rich Plasma) therapy is a regenerative medicine technique that utilizes the patient’s own blood to stimulate healing and rejuvenation in various parts of the body. It is a non-surgical, minimally invasive treatment that has gained popularity in recent years for its ability to promote natural healing and tissue repair.
PRP therapy works by extracting a concentrated sample of the patient’s own platelets, which are rich in growth factors and other beneficial proteins. This platelet-rich plasma is then injected back into the targeted area, such as a joint, tendon, or muscle, to stimulate the body’s natural healing processes.
How does PRP therapy work?
The process of PRP therapy typically involves the following steps:
- Blood draw: A small sample of the patient’s blood is drawn, usually from the arm.
- Centrifugation: The blood sample is placed in a centrifuge, which spins the blood at high speeds to separate the different components, such as red blood cells, white blood cells, and platelets.
- Platelet concentration: The platelets are isolated and concentrated, resulting in a platelet-rich plasma (PRP) solution.
- Injection: The PRP solution is then injected back into the targeted area of the body, such as a joint, tendon, or muscle, to promote healing and tissue regeneration.
The growth factors and proteins present in the concentrated platelets are believed to stimulate the body’s natural healing processes, leading to reduced inflammation, improved tissue repair, and enhanced regeneration. PRP therapy is performed in an outpatient setting, such as a clinic or doctor’s office, and typically takes less than an hour.
What conditions can PRP therapy treat?
PRP therapy has been used to treat a variety of musculoskeletal and soft tissue conditions, including:
- Osteoarthritis
- Tendinitis (e.g., tennis elbow, Achilles tendinitis)
- Ligament sprains and tears
- Muscle strains and tears
- Chronic joint pain
- Plantar fasciitis
- Rotator cuff injuries
- Meniscus tears
- Degenerative disc disease
PRP therapy can also be used to promote healing and rejuvenation in other areas of the body, such as the skin, hair, and even the face.
What are the benefits of PRP therapy?
The potential benefits of PRP therapy include:
- Reduced pain and inflammation
- Improved joint function and mobility
- Enhanced tissue healing and regeneration
- Delayed or avoided need for more invasive treatments, such as surgery
- Minimally invasive and non-surgical procedure
- Utilizes the patient’s own natural healing abilities
- Can be used in combination with other treatments for synergistic effects
PRP therapy is often considered a safe and effective alternative to more traditional treatments, such as steroid injections or pain medication, for certain musculoskeletal and soft tissue conditions.
Is PRP therapy safe?
PRP therapy is generally considered a safe and well-tolerated treatment. Since the PRP solution is derived from the patient’s own blood, there is a very low risk of adverse reactions or rejection. However, as with any medical procedure, there are some potential risks and side effects, including:
- Mild pain or discomfort at the injection site
- Temporary swelling or bruising
- Infection (rare)
- Nerve damage (rare)
To minimize the risk of complications, PRP therapy should only be performed by experienced, licensed medical professionals with appropriate training. The PRP injection should always be performed with image guidance to ensure accurate delivery of the PRP treatment to the targeted area.
What is the recovery process like after PRP therapy?
The recovery process after PRP therapy can vary depending on the specific condition being treated and the location of the injection. In general, patients can expect the following:
- Mild to moderate pain or discomfort at the injection site for the first few days after the procedure
- Temporary swelling or bruising in the treated area
- Restrictions on physical activity for a period of time, as recommended by the healthcare provider
- Gradual improvement in symptoms over the course of several weeks to months
Patients are typically advised to rest the treated area, and they may also be prescribed pain medication if needed. Physical therapy exercises may be recommended to help promote healing and restore function. It’s important for patients to follow the post-treatment instructions provided by their healthcare provider and to report any persistent or worsening symptoms.
How long does it take to see results from PRP therapy?
The time it takes to see results from PRP therapy can vary depending on the specific condition being treated and the individual’s response to the treatment. In general, patients may begin to notice improvements in their symptoms within a few weeks of the procedure, but it can take several months to see the full effects.
Some key factors that can influence the timeline for results include:
- The severity and chronicity of the condition being treated
- The location and extent of the injury or damage
- The patient’s overall health and healing ability
In some cases, patients may require more than one PRP treatment to achieve the desired results. The healthcare provider can provide a more specific timeline based on the individual patient’s case and treatment plan. It’s important for patients to be patient and to follow the recommended treatment plan, as PRP therapy is a regenerative process that takes time to fully take effect.
Is PRP therapy covered by insurance?
Most private insurance companies and Medicare do not cover PRP therapy. In most cases, patients will need to pay for the procedure out-of-pocket. The cost of PRP therapy can vary depending on geographic location, the specific body areas in need of treatment, the use of specialized processing systems to produce the PRP, the use of image guidance to perform the injection, as well as the experience and expertise of the healthcare provider performing the procedure.
Is all PRP therapy the same?
Not all PRP therapy is created equal. There are over 50 different PRP processing systems on the market, which produce different types of PRP. Some systems produce “weaker” PRP which may be insufficient to treat certain orthopedic conditions such as osteoarthritis. It is important to see a health care provider who has expertise in PRP therapy to ensure that you are getting adequate PRP for your condition.
Can PRP therapy be combined with other treatments?
Yes, PRP therapy can often be combined with other treatments to achieve synergistic effects and optimize outcomes. Some common combinations include:
- PRP therapy and physical therapy:
- PRP therapy can be used to stimulate healing and tissue regeneration, while physical therapy can help to restore function, improve range of motion, and strengthen the affected area.
- PRP therapy and shock wave therapy:
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- In some cases, PRP therapy may be used in conjunction with shock wave therapy, as both can stimulate healing of injured tissues using different mechanisms.
- PRP therapy and other regenerative treatments:
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- PRP therapy can be combined with other regenerative treatments, such as stem cell therapy or prolotherapy, to further enhance the body’s natural healing and tissue repair processes.
- PRP therapy and surgical procedures:
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- PRP therapy can be used in conjunction with surgical procedures, such as tendon or ligament repairs, to help promote faster and more effective healing.
The specific combination of treatments will depend on the individual patient’s needs and the healthcare provider’s assessment of the most appropriate and effective approach. It’s important for patients to work closely with their healthcare provider to understand the rationale and potential benefits of any combined treatment plan.
Who is a good candidate for PRP therapy?
PRP therapy may be a good option for individuals who meet the following criteria:
- Suffering from an orthopedic injury or condition, such as osteoarthritis, tendinitis, or muscle/ligament tears
- Have tried more conservative treatments, such as physical therapy, anti-inflammatory medications, or steroid injections, without achieving satisfactory results
- Are generally healthy and do not have any underlying medical conditions that could interfere with the healing process
- Are willing to commit to the treatment plan, which may include physical therapy, a period of rest, and sometimes more than one PRP treatment
- Are not currently taking certain medications, such as blood thinners, that could interfere with the PRP therapy
- Have realistic expectations about the potential benefits and timeline for results
It’s important to note that PRP therapy may not be suitable for everyone, and the healthcare provider will carefully evaluate each patient’s individual case to determine if it is the most appropriate treatment option.
To learn more about PRP therapy and whether it may be a suitable treatment option for your specific condition, schedule a consultation with a qualified healthcare provider in your area. They can provide a personalized assessment and treatment plan to help you achieve your health and wellness goals.
Conclusion
PRP therapy is a promising regenerative medicine technique that has gained popularity in recent years for its ability to promote natural healing and tissue repair. By utilizing the patient’s own platelets and growth factors, PRP therapy can be an effective treatment for a variety of musculoskeletal and soft tissue conditions, including osteoarthritis, tendinitis, and muscle/ligament injuries.
While PRP therapy is generally considered safe and well-tolerated, it is important for patients to work closely with experienced healthcare providers to ensure a successful and effective treatment plan. The recovery process can vary, but most patients can expect to see gradual improvements in their symptoms over the course of several weeks to months.
PRP therapy can also be combined with other treatments, such as physical therapy or other regenerative procedures, to optimize the outcome. Patients should carefully evaluate their options and work with their healthcare provider to determine the most appropriate and cost-effective treatment plan.
Overall, PRP therapy offers a promising and innovative approach to addressing a range of musculoskeletal and soft tissue conditions, and it continues to be an area of active research and clinical investigation.
Feb 22, 2024
Knee pain can be debilitating, affecting an individual’s mobility and quality of life. Whether it’s caused by injury, arthritis, or other underlying conditions, finding an effective treatment for knee pain is crucial. One innovative solution gaining popularity is MFAT (Micro-fragmented Adipose Tissue), a minimally invasive procedure that uses a patient’s own fat tissue to promote healing and relieve knee pain. In this article, we will explore the causes of knee pain, introduce MFAT as a treatment option, delve into how MFAT works to relieve knee pain, discuss the benefits of this procedure, and provide an overview of the MFAT procedure for knee pain. If you’re suffering from knee pain and seeking an effective solution, read on to discover if MFAT is the right choice for you.
Understanding Knee Pain and Its Causes
Before diving into MFAT as a treatment option, it’s essential to understand the causes of knee pain. Knee pain can arise from a variety of factors, including injuries, overuse, or underlying medical conditions such as arthritis. Injuries like ligament tears, meniscus tears, or fractures can lead to acute knee pain that requires immediate attention. On the other hand, chronic knee pain caused by arthritis or other degenerative conditions can develop gradually over time and worsen with age. Identifying the root cause of knee pain is crucial in determining the appropriate treatment approach.
Introduction to MFAT Treatment for Knee Pain
MFAT is a cutting-edge regenerative medicine treatment that offers a promising solution for individuals suffering from knee pain. This innovative procedure utilizes the patient’s own adipose tissue, commonly known as fat, to promote healing and alleviate pain. Unlike traditional treatments that focus on managing symptoms, MFAT targets the underlying cause of knee pain by harnessing the regenerative potential of fat tissue. By introducing a concentrated dose of adipose-derived cells into the affected knee joint, MFAT stimulates the body’s natural healing process and reduces inflammation, resulting in pain relief and improved function.
How Does MFAT Work to Relieve Knee Pain?
MFAT works by harnessing the therapeutic properties of adipose tissue to promote healing and alleviate knee pain. The procedure begins with a minor lipoaspiration technique, where a small amount of fat tissue is harvested from the donor site (such as the abdomen or buttocks) using a specialized cannula. The harvested fat tissue is then processed using innovative technology, which gently cleanses and concentrates the adipose-derived cells while preserving their regenerative properties. Once processed, the concentrated adipose-derived cells, along with their surrounding extracellular matrix, are injected into the affected knee joint. These cells release growth factors and anti-inflammatory substances, stimulating tissue repair, reducing inflammation, and ultimately relieving knee pain.
Benefits of MFAT for Knee Pain Relief
MFAT offers several advantages over traditional knee pain treatments, making it an appealing option for individuals seeking long-term relief. Firstly, MFAT utilizes the patient’s own natural fat tissue, reducing the risk of adverse reactions or rejection. Since the adipose-derived cells used in the procedure come from the patient’s own body, there is no need for foreign substances or synthetic materials. Additionally, MFAT is a minimally invasive procedure that can be performed in an outpatient setting, minimizing the risks associated with more invasive surgical interventions. The recovery time is shorter compared to traditional surgery, allowing patients to return to their daily activities sooner.
MFAT Procedure for Knee Pain
The MFAT procedure for knee pain is a relatively simple and straightforward process. It begins with a thorough consultation with a qualified physician who specializes in regenerative medicine. During the consultation, the physician will assess the patient’s knee pain, review medical history, perform a physical examination, and determine if MFAT is a suitable treatment option. If deemed appropriate, the lipoaspiration procedure will be scheduled. On the day of the procedure, the patient will undergo a local anesthetic to numb the donor site. A small incision is made, and the fat tissue is gently suctioned out using a specialized cannula. The harvested fat tissue is then processed, and the concentrated adipose-derived cells are injected into the affected knee joint using a thin needle under ultrasound guidance. The entire procedure typically takes less than two hours, with minimal discomfort and downtime for the patient.
Is MFAT the Right Solution for Your Knee Pain?
Knee pain can significantly impact an individual’s quality of life, limiting mobility and causing discomfort. If you are seeking an effective solution for knee pain, MFAT may be the answer you’ve been looking for. This innovative regenerative medicine treatment offers a minimally invasive approach that targets the underlying cause of knee pain, promoting healing and reducing inflammation. With its numerous benefits, including the use of the patient’s own adipose tissue and shorter recovery time, MFAT provides an appealing alternative to traditional knee pain treatments. However, as with any medical procedure, it’s essential to consult with a physician to determine if MFAT is the right solution for your specific condition. Take the first step towards relieving your knee pain and regain your mobility by scheduling a consultation with a regenerative medicine specialist today.
Schedule a consultation with a regenerative medicine specialist at San Diego Orthobiologics Medical Group today to explore if MFAT is the right solution for your knee pain. Don’t let knee pain hold you back any longer.
Jan 2, 2024
Join Dr. Rogers and Dr. Evangelista for a FREE Webinar on the Non-Surgical Management of Achilles Tendon Injuries where they will discuss common causes and innovative treatment solutions to restore patients back to better health.
When: January 9, 2024
Time: 12:00pm PDT
Register HERE for the Webinar
Dec 20, 2023
Cellular therapy has emerged as a groundbreaking medical treatment, revolutionizing the field of healthcare. By utilizing the body’s own cells, this innovative approach seeks to restore health and promote healing in a way that traditional medicine cannot always achieve. In this article, we will delve into the world of cellular therapy, exploring its definition, history, mechanism of action, benefits, and more.
What is Cellular Therapy?
Cellular therapy, also known as cell therapy or cytotherapy, involves transplanting living cells into a patient’s body to replace or repair damaged cells or tissues. These cells can be derived from the patient’s own body. In most circumstances, platelets or mesenchymal cells are used for this type of therapy. Platelets are the tiny cells in a patient’s blood that secrete numerous growth factors which are critical in healing. Mesenchymal cells are multipotent cells found in fat or bone marrow and have the ability to differentiate into bone, cartilage, tendon/ligament, and muscle. Cellular therapy aims to enhance the body’s natural healing processes and restore proper functioning.
History of Cellular Therapy
The history of cellular therapy can be traced back to the late 19th century when bone marrow transplantation was first attempted. This procedure involved the transfer of healthy bone marrow cells to individuals suffering from blood disorders, such as leukemia. Over the years, advancements in medical research and technology have expanded the applications of cellular therapy to various conditions, including organ transplantation, immune system disorders, neurodegenerative diseases, and orthopedics.
How It Works
Cellular therapy harnesses the power of cells to promote healing and restore health. The process begins with the collection of the desired cells, which are then prepared for transplantation. These cells are carefully administered to the patient, typically through an image guided injection targeting the affected area. Once inside the body, the cells integrate themselves into the surrounding tissues and initiate the healing process. They either replace damaged cells directly or stimulate the body’s own cells to repair and help grow new tissues, leading to improved health outcomes.
Benefits of Cellular Therapy
Cellular therapy offers numerous benefits, making it a promising treatment option for a wide range of orthopedic conditions. One significant advantage is its ability to provide personalized medicine. Since cellular therapy utilizes the patient’s own cells, the risk of rejection or adverse reactions is significantly reduced. This personalized approach also allows for targeted treatment, increasing the likelihood of successful outcomes.
Additionally, cellular therapy can potentially address previously untreatable or difficult-to-treat conditions. By focusing on the root cause of the disease and promoting natural healing, cellular therapy offers new hope for patients who have exhausted conventional treatment options. Moreover, it can potentially reduce the need for invasive surgeries and lifelong dependency on medication, improving the overall quality of life for patients.
Conclusion
In conclusion, cellular therapy represents a remarkable advancement in medical science, offering a new frontier of treatment possibilities. By harnessing the power of cells, this innovative approach has the potential to transform the lives of countless individuals suffering from various orthopedic conditions. With ongoing research and advancements, cellular therapy holds promise for the future of healthcare, providing hope for individuals seeking more effective and personalized treatment options.
San Diego Orthobiologics Medical Group is a leading provider of cellular therapy for the relief of arthritis, chronic tendon injuries, and other orthopedic conditions. Our treatment plans typically involve other forms of therapy to maximize improvements in biomechanics, fitness, nutritional status and healing capacity.
Aug 14, 2023
Hand and wrist injuries can occur to an individual either suddenly, such as in the case of a sprain, or over time, such as through repetitive use injuries. In either case, the sufferer needs to know about the pain relief options that are available to them. Given the myriad of different ways that one can injure their hand and/or wrist, it is challenging to diagnose a patient without a full medical evaluation. The good news is that cell therapies provide a bright future in pain relief for individuals suffering from hand and wrist pain of most varieties.
What is Cell Therapy?
The use of cell therapy is rapidly expanding as many more people become informed of the option and become more familiar with it. Dr. Rogers of the San Diego Orthobiologics Medical Group offers the following explanation of what cell therapy is and why it matters:
Cell-based therapies are a versatile and powerful treatment method that is transforming orthopedic medicine. Conditions such as arthritis, tendon tears or disc tears traditionally managed with medications or surgery can now be treated with your own cells to provide years of relief.
The natural healing benefits that many patients experience are significant and point to the idea that cell therapy should be a first-choice option for many patients. If they can use their own body’s cells to work on healing themselves, why not give this a try.
The Types of Cell Therapy You May Be Offered
Different types of cell therapies might be useful when working on finding relief from hand and wrist pain. For example:
- Platelet-Rich Plasma (PRP) Injections – Platelets from the patient’s own blood are concentrated and then injected to area of damaged tissue to stimulate healing. These platelets release growth factors and proteins that promote tissue regeneration.
- Adipose (fat) tissue injections or Bone marrow injections – Cells are harvested from patient’s fat tissue or pelvic bone. These cells spur the production of new blood vessels, awaken stem cells and encourage newly forming cells to produce collagen and other proteins essential for creating new healthy tissues. These specific cells can stimulate tissue regeneration.
Minimal Invasiveness and Recovery Time
When looking for medical interventions for pain relief, most patients are concerned with two primary things. First, they want to ensure that the procedure they receive will be as minimally invasive as possible. Secondly, they want something that doesn’t involve a long recovery period if they can avoid it. After all, we all have busy lives and can’t afford to miss out on too much of it. The good news is that cell therapy is minimally invasive and involves only a short recovery period.
Reduced Pain, Improved Mobility
The two biggest things that those suffering from hand and wrist pain want from any treatment that they receive are improved mobility and reduced pain. Those who opt to undergo cell therapy will receive both. These therapies provide cells to areas within the body that are degenerated and need care. Doing so offers faster recovery periods and results in far fewer complications than other treatment options such as surgery. All of this is critically important when it comes to receiving the care and support that you require.
You can receive the care you require and get back to living the life that you want to live. Don’t hesitate to contact us and learn more about the cell therapy you can receive to get past the pain you are suffering from now.
